I went in a different direction than Dave. I went for an Around-the-Walls design. Along the walls are 2 ft wide tables. In the open sides the tables are 4 ft wide. The widths where chosen to allow for easy access to all parts of the layout. Access to the 5 ft by 5 ft center is via a 2 ft wide passage that could be crossed by lift-up, lift-out, drop-down, duck-under, swing-out...
There are two loops for continuous running and a yard with a lead letting 3 people operate. At the top is a combination crossover/passing siding. There's plenty of room for accessories. If more table area is desired the table widths can be increased. While the layout can be operated in the center, I envision most of the time the operators and viewers will be on the outside looking in.
Jan