If pursued, please do something different, something that may attract a broader group of collectors, not just some repainted version of a 400E, 381, or anything that's been done a million times before in a million different paint schemes.
The New Haven streamliner would be good, and also, but I doubt that tooling would be developed for 500 pieces. A reuse of existing tooling would work with an O gauge tinplate PE (using existing engines like a 260, and maybe some of the Ive style 1685 cars would be acceptable in O, even though a repaint). After seeing the train at the end of the movie, who wasn't disappointed that the Lionel offering was "modern".
It appears that the M&AR Blue Goose would be easily accomplished by double heading a Flying Yankee power car, with an extended body. It would look more accurate than a Prospector, and cheap to make as well.
There are just too many redone, remade, Cohen, MTH, Williams versions of 1764E's, 400E's, 381's, 408's. The market is saturated with shiny versions of these. Just please do something else if possible.