Well, it depends upon what type of yard. If it is an engine service area, there should be no issues. If it is for car storage, maybe. On longer trains, if you have lighter cars towards the front, you'll likely be dealing with derailments.
On our club's modular layout, backing trains through a 90 degree 072 curve frequently causes problems.
This Primer has some really good information. I'm not going to say "impossible", but just due to available real estate you will be doing some compromising.