Yes, all the time. It's easy - just do it.
The only thing to do first is to give each remote a unique DCS ID#:
Menu/System/Remote Setup/Edit Remote Addr
This and a whole lot more is all in "The DCS O Gauge Companion 2nd Edition", now available for purchase as an eBook or a printed book from MTH's web store site! Click on the link below to go to MTH's web page for the book!