Options? - 22' x 11' Room

Look at choosing a table height that will permit you to put you bench underneath the table.  If you search for threads on table height you'll find that they vary from mid-thirties ti low fifties inches..  The older people seem to get, the higher the table.  A high table is easier to work under. 

Plan on a lift up or lift out section at the door (You didn't say if it opened in.) so you don't have to duck under. 

You max reach is about 3 feet so unless you have access from both sides.  The Minimum aisle with is 2 feet, but 3 feet is better and permits people to slip past each other.

I have an around the room layout (14' x 28') with a 4' wide peninsular in the middle.  The ATW oval is 2' wide (except for being 3' on one side).  The aisles are 2' and 3'.  My minimum radius is O72 and the largest is O90.

Jan

If you use 16' x 11.5' you leave working and stuff space near the bench and eliminate the door issue. Still need a lift-out, fold-up, or fold-down.

What Jan said.

As Jan said, you might want to consider building the layout so that part of it is above the workbench -- high enough to give you work room, but low enough to operate. What I've found at the club is that our staging room's benchwork height at 54" is very comfortable for reaching and viewing equipment (the rest of the layout is at 40" to be kid friendly). When I build at home 54" will be the height of the layout deck. That would give you roughly 20" headroom over a 30" high work bench.

This would give you a nice around-the-walls layout you could easily duck under (or add a lift-up/drop-down if you wanted). The layout bench over the workbench could be narrower to keep things from becoming claustrophobic.

Just a thought.