The Weaver "Ultra Line" RS-3s with fixed pilots can be made to run very well--probably better than ANY vertically-motored diesel. They had large Pittman motors and can be fitted with a very large flywheel--or even two--for serious coasting! They can easily be geared down so that 800 RPM = 4 scale mph. That's good enough to earn full points in an NMRA contest without any need of closed-loop "speed control." All this, and there is still enough room inside for a fully-detailed cab. The centrally-motored drive will negotiate O42 curves; the body-mounted couplers will limit your minimum diameter.
Although this drive can be made to run slowly and smoothly, it's a bit light-duty. There are a lot of nylon gears, U-joints, etc. After 35 years, you might encounter shrinkage and splitting. The good news is, replacement parts are still available from P&D Hobby (pdhobbyshop.com) at a modest cost. If you change the ratios or mess with the nylon drive chain, make sure the flashing/burrs on each molded link are on the outside of the chain (not the sprocket side) or it will inhibit smooth operation.
Another drawback is that these diesels are feather-light. You don't have to worry about zinc pest, because there's almost no metal!! The last generation made by Weaver was sold with one rubber-tired axle. Even though I hate rubber tires, I added a second rubber-tired axle to mine, for a total of four tires. (With this design, you can easily replace wheelsets--you could do a full 2-rail conversion with nothing more than hand tools!) I also added at least a POUND of lead (custom weights built from laminations of sheet lead and contact cement.) I believe the shell and chassis are made of styrene. Unlike the ABS plastic used by other brands it's brittle, and won't withstand a lot of abuse. Couple carefully, because the stock body-mounted couplers pivot on styrene posts which are easily broken.
Bottom line, if you have a little patience and an appetite for customization, the Weaver units are the most realistic and smoothest-running RS3s yet made for 3-rail O. I don't have the room for O72 curves anymore, but when I did, I had a lot of fun upgrading and running mine! I only wish someone would have made a sturdy metal frame for these as they did for the contemporary Red Caboose GP-9. Good luck. Whatever you decide to go with, please post up some pics to show off your work!