First, I did look on the forum for an answer and I found a lot of them, that is why I am asking this question again with specifics values to our situation
We are building new modules and smallest planned diameter for parallel tracks is an O-89 / O-96 (dog bone outside module) the largest is O-113 / O-128 (standard inside module 4 of these make a big rectangular layout)
My concern as you have guessed is how close can the track be center to center I have seen 5.5" and 6" as the standard, I want to make sure that I am safe with 5.5". Our module 'runners' have just about every loco there is in terms of size.
The distance between the center rail and plexi-glass is 3.5" at apex of the curve (O-128) and 5.25" on the straight a ways.