I have a very basic layout that uses 072 radii (for outer loop) and 0-54 radii (for a long passing siding.) It is designed mostly for maximum operating variety. I use MTH DCS for control of engines and accessories. In order to allow reversing of engines I have designed an 0-72 WYE with a stub end passenger yard. Although the 0-72 WYE takes up a lot of space (4 feet by 6 feet) it provides a way to back scale size passenger trains into the yard and allows the engine to escape and then reverse direction as necessary. I also have two 0-72 crossovers which allow transition from the 0-72 loop to the inner 0-54 passing siding track. The passing siding allows for either holding trains or for train makeup and peddler freights. I operate mostly MTH Premier PS-1 and PS-2 engines so the 0-72 radii is essential. I occasionally run Williams and conventional size Lionel equipment.
The layout fits a space approximately 15 feet by 13 feet.
When I am not running full size passenger trains I remove the passenger equipment from the layout and run modern intermodal trains using multiple engines.