My biggest steam engines are a Williams brass 4-8-4 and a Lionel 4-8-2, my biggest diesels are a Williams E7 and a GGD E7. My other engines are:
Williams brass USRA 2-8-2 (2)
Williams brass USRA 4-6-2 (2)
Williams by Bachmann USRA 4-6-2
MTH RailKing 2-8-0 (2)
MTH USRA Imperial 0-6-0
Weaver brass 4-6-0
Atlas GP9
Lionel GP9
MTH RailKing NW2
Weaver RS3
MTH RailKing RS3
Atlas F3
Everything (engines, freight, and passenger cars) I have has fixed pilots and Kadee couplers.
With Kadees, 40' freight cars, and 18" passenger cars I would not go below 054 curves. With 50' freight cars and 21" passenger cars I would not go below 072 curves. Most of my curves are 072 (now 2-railed by removal of middle rail), but I do still have a couple of 054 curves on the layout.
You may find on some of the better detailed models some underframe stuff made have to be cut off and some end detail stuff may catch on the cars next to it. You can always get longer shaft Kadees and/or cut the sides of the coupler boxes to allow for extra swing. They also make couplers with different heights so large shims aren't necessary, most cases the shims are thin or non-existent.
The hardest part is making that first cut (if needed). A lot of today's models come Kadee ready and there's one of our fellow forumites who's making 3D printed parts for diesels.
Be prepared to have to cut, dremel, make, glue, drill, tap, touch up paint, because that's gonna happen. The manufacturers are not where they need to be as far as ease of conversion, yet.
I recommend you take 2 cars and give it a go.