I have been giving my new layout due consideration, and with a 42" width and 108" length, with minimal scenery (no 400lb plaster of Paris landscaping) the table can be designed with relatively light weight construction like the work bench I designed and built for relocation as needed. It has supported me leaning on it for years, while pondering the mysteries of numerous HO contraptions. With a layout all it has to support are a few O27 trains running in circles.
The attached pic is of the workbench in question. The only added feature I am planning is to put a layer of 3/8" Homasote over the entire top surface and glue bond it with liquid nails to the 1/4" plywood top. The legs may be a little beefier 2"x2", thinking more along the lines of two 1"x3" in an "L" configuration, but still relatively light weight and movable.