I really liked using Empire Express when I tried the demo years ago, but it is so out dated I'm not even sure it'll still run under the current version of OS X. Before it went to a pay model I was able to use SCARM very well within PlayOnMac. Only the 3D didn't work, but I never used it anyway so I had no issues. The paid version of SCARM should still work in PlayOnMac.
EDIT: Wow, Empire Express has been brought back to life. I need to try the new version out and see how it compares to the one I used. I may have to get it as it was really good back then.