I have used water misters in a large Christmas train layout in the past. I used them in a small Halloween setup to give the fog appearance from part of our real water lake. It give a good appearance but it does make somewhat of a mess with the water. Please take in consideration that this display was open and operating 8 hours a day for 30 days. So the 250+ hours of these producing the mist is well over the hours that they would be used in a home layout. The mist did not interfere with the operation of the train display in any way.
It did saturate the plywood near the edge of the real water lake and it did turn green from the ground covering that was on top of the plywood. But we replace the plywood yearly anyway.
Here are some photos of that display.
In photo below you can see the fog to the rear of the Halloween buildings.
Below you can see the fog coming through under the operating highway meeting the 2 waterfalls one on each side of the lake.
Here you can see under the highway with the foggers turned off. The lake about 40" x 80" in size.
Here is a close up of the fog from the opposite side of the Halloween buildings. The misters we used have built in orange lights that add to the effect.
This is what it looked like from behind the Halloween buildings.
Another view from the Halloween building side.
A close up of the misters in action.
Another view from the opposite side.
Close up from the building side, this display was 18' x 44' in size with 5 different levels with trains on 4 different levels, 16 separate tracks operating 16 MTH trains on those tracks. The longest track is about 120' long which crosses over 2 different bridges one is 8' long and another is 12' long. Over 60 Department 56 buildings 2 - 12 foot long real water waterfalls and over 200 animated items will be in the display.