OK, there is a way to use both Transformers and not have issues with power.
However, a CW80 is the last transformer I would try to use with a MTH engine. They do not play well together.
Anyway, To get away with the mix, make short blocks in your layout. Power 2 separate DCS channels with your 2 transformers.
Connect one channel to every other block on the layout. then connect the remaining blocks to the second channel.
This splits the load across both transformers with bridging happening when your lighted passenger cross the breaks forming the blocks.
A partial solution to the bridging is to add a pair of diodes to each car between the pickups and the rest of the car.
This will reduce the current flow from channel to channel.
Point each diode the same way on a car. Both away from the trucks or both toward the trucks. Alternate the diode direction on every other car so you balance the load on the positive and negative sides of the sine wave.
This will also cause the lights to be running on half the power, so they will not get too hot or burn out as fast. But they will not be as bright, which actually looks better to me.