Both my mom and dad grew up in Bentleyville, PA. This is a small town along the Ellsworth Branch of the Pennsylvania that connected with the Monongehela Division in the town of Monongehela, PA on the river of the same name. Their families were coal miners and so was my dad until his early 20s (he started at 14) when he got laid off and was recently married. So they moved north of Pittsburgh to Ambridge PA where got a job in a Jones and Laughlin Steel Plant (J&L Steel). That was about 20 years before I was born.
When I was refining my ideas for something to model, I stumbled onto a magazine with track charts of the PRR Monongehela Div and all the branches. I had always thought of the PRR as the 4 Track main that went by the town I grew up in. But the Mon Div had all kinds of single track and the Main line was double track. I originally very very loosely modeled the Ellsworth Branch through Bentleyville and Ellsworth to Cokeburg. When I moved in the late 80s from western Ohio to Michigan, I decided that focus either too constraining, or required to much imagineering to run much other than coal trains. So I looked at my track charts and found the connection from Greensburg to the Mon Div main at West Brownsville, that sort of forms a loop to south and then back to Pittsburgh and points west. And it was single track in fairly modern times. As most of you have figured out, multiple track mains eat a lot of real estate.
So now I have built a model of the line from just south of Greensburg on the Pittsburgh Div main through Brownsville with staging tracks feeding both directions. I model a yard at Youngwood, which is much much compressed. the track is still very loosely based on the prototype but is easier to justify a few general through freights which actually did run from Pitcairn to Uniontown. I decided mine through past uniontown and on to Conway Yard and originate in Enola, both locations as staging tracks. I also kept passenger service still running with a secondary through train and a commuter local in each direction. With connections at each end to major mains it is much easier to tell people there is through freight with an M1 coming by.
So I still model the area that my family came from, but not quite the hometown. On the other hand, I have a Spang Chalfant pipe plant from my hometown, an American Rolling Mill (makes rolled metal roofing) from my Ohio employer who started that way, and an Isaly's Dairy plant which was common over that area with stores in every small town. I also have Newman Packing Co named for my father in law who loved his steaks. And I have a small general store/post office named after my Grand Father - Zilka's general store. The rolling stock includes two JLSX tank cars for hauling Coke Byproducts using in making tar and other products. JLSX is the private reporting marks for J&L steel and both cars are "Return to Aliquippa Works" where my dad worked.
So there is a lot inspiration from family and personal history on my layout.