Well, the "and then stop" part is easy..
The remainder can be done in a manner similar to the DCS Loader when it is controlling the TIU over a USB emulated RS-232 for sound file transfer, etc. The external microcontroller would have to unlock the interface (a small Speck of code for this) and send a sequence of ASCII commands to set whatever settings you want to set.
Its my experience on original TIU, that the radio and the 9-pin DB can function at the same time.