The more modern "3-2" locos - DCS-compatible engines with PS2/3, that can be run in either 2- or 3-rail environments, achieved by flicking a switch and easily removing the center-rail pickups...I do not think that they would be compatible with your system..
The older, strictly 2-rail MTH items had no sound or command, essentially just a headlight and a big ol' Pittman DC can motor, should run on your ancient DC layout. I had a flirtation with 2RO, DC - I bought a used MTH Empire State Express 4-6-4. Beautiful. Simple.
I envy you your "ancient" DC 2R layout, to be honest. There are so many literal and figurative electronic moving parts and possible failure points in modern 3RO that it's just getting - has gotten - annoying. It's become another anxiety nexus. Too late for me, though.