Sometimes, but not always. Lionel has made many locos over the course of many decades so I would say in general, no: don't assume they will be. But in a lot of cases the front and even the rear trucks and wheels can be interchanged, etc.
I have done this in particular among the Lionchief Plus locos, removing and changing trucks for other Lionel trucks-I bashed two of my steamers, Hudson and Pacific, into acceptable (to me, at least) scale models of smaller, older locos. I also played "truck games" with a Legacy Mogul I did not like and changed around alot, actually adding a small rear truck to make it a 2-6-2, etc. About 25% of the time the new truck(s) just bolt right on. About 50% of the time, some slight modification, washer as spacers, etc., has to be done. About 25% of the time it requires more work, perhaps enough that a person might give up.