Okay, 72 inch radius would be great. But most or many of us do not have the space. Personally I wanted an "operations based" layout meaning trains doing something with switching and transfers and some secondary passenger trains. I could never be satisfied with a big loop. My basement would let me do a 10 ft radius oval. But that just does not appeal to me. I settled on 52 inch radius and can run everything I have reliably and I have a trackplan that hosts up 8 operators in various jobs. so the big compromise on radius gave me the kind of layout I wanted.
I have been in 2-rail O scale since about 1976-78. My original layout was alll handlaid track and 48 inch radius. I learned back then that most steamers up to a mikado will run on those curves and all diesels I had access to. Also I had a string of Walthers full length passenger cars and they were fine on the curves too.
An interesting tidbit, brass from golden era of the 70s through about 2000 at least almost always had sprung drivers that worked. 6-axle diesels actually adjusted to rough track and stayed on the rails. Steamers did the same. They could take little bumps and one wheel at a time would go up or down as needed.
Now the descendents of the 3 rail market have ridgid frames on the 6-axle diesels. They are actually less forgiving and less prototypical (in that regard) than the old stuff.