Choosing a command system (TMCC, Legacy or DCS) often boils down to personal preference. At the least both systems can operate multiple trains on the same track remotely, operate switches and accessories, and support conventional operation of non-command equipped locomotives. Lionel does offer TMCC-equipped turnouts as part of its FasTrack line, but any switch machine can be controlled by either TMCC or DCS - you just need to purchase the necessary module (called an SC-2 for TMCC, or an AIU for DCS). FasTrack is a great system for smaller layouts, but if you prefer Ross, Atlas, or Gargraves track, the feature isn't much of a selling point.
You mentioned having a TMCC locomotive, with plans to acquire more. If most of your locomotive fleet will be TMCC equipped, purchasing TMCC would be a good start. Legacy-equipped locomotives run just fine under TMCC, so you do not necessarily have to purchase the Legacy system. On the other hand if most of your future fleet will be DCS-equipped, then starting with DCS is a logical choice.
Now what if you plan on operating both DCS and TMCC equipped locomotives? The good news is both systems will work well together on the same layout. DCS and TMCC communicate with the layout differently (DCS uses the track; TMCC uses radio waves similar to RC cars and planes), and as such have slightly different wiring schemes. Most operators will recommend wiring your layout for the DCS system (using matched pairs of wires radiating from a central point, aka "star wiring"), and then adding the TMCC remote and receiver. As an extra bonus, the DCS remote can even control TMCC-equipped locomotives with the help of a special adapter cable between the DCS base (called a TIU), and the TMCC base.
I've avoided delving too much into Legacy, only because Legacy muddles the waters a bit. DCS cannot operate Legacy locomotives set to the Legacy mode, nor can DCS activate any of the special features that only Legacy supports.
I know this is a lot of information to digest, but when I first got into command control, I read Command Control for Toy Trains by Neil Besougloff. It's an excellent primer for command operations, and breaks down the differences between DCS and TMCC. Most sources have the book for less than $20, which is a nominal investment given the pricetag of a basic TMCC or DCS system.
-John