The former PRR Main Line was never really a major carrier of through freight, except for east of Parkesburg, where the low grade was merged with the Main Line as a 4 track railroad. While freights to North Jersey diverged onto the P&T branch at Thorndale, relieving the Main Line of a large portion of its freight traffic, those bound for Philly stayed on the Main Line. Ironically, this meant freight had to mix with commuter trains for the 20 plus miles west of Philly, but was on its own right of way in the bucolic farmland to the west. A low grade line for freights to Philly was planned in the early 20th century that would follow the Darby Creek to the 52nd street freight yards from the Frazier area (site of Septa's shops just west of Paoli) but was never completed due to high land acquisition costs and improved signaling that raised the capacity of the Main Line. As mentioned above, some through freights did travel all the way west to Cork (Lancaster) on the Main Line, before diverging onto the Columbia secondary to head to Enola. I also believe some trailer trains and other fast freights used the Main Line all the way to Harrisburg Terminal on a regular basis.
As for tracks, four were maintained all the way to Cork (Lancaster) and two to the west at the height of the Pennsy's traffic levels. Cork to Parkesburg was cut from four to two tracks in the early 60's, and it wasn't long before decreasing levels of traffic led to Thorndale to Glen Lock being cut back to three tracks. As through freight was removed from the Main Line in the 80's, more tracks were removed leaving the line with only three tracks west of Paoli, two tracks west of Parkesburg, but still with four tracks east of Paoli. The line retained this configuration for decades, although some tracks were in poor condition and rarely used. Presently (if it hasn't happened already) upgrades to the route will remove the dilapidated third track between Paoli and Parkesburg. In summary: today the route has four tracks east of Paoli, and two tracks west to Harrisburg.
As for catenary, Philly to Paoli was electrified in 1915, and west of there in the 30's. I believe most of it is original, although Amtrak would like to replace the 1915 structures in the near future. Of great interest to me - since I lived along the line in the 80's - was the fact that late in this decade the catenary was in such bad repair west of Parkesburg that it was in effect out of service, and Amtrak had to use diesels on its Harrisburg trains.
With regards to towers, I'm not sure if any are left operating. The Main Line was a holdout for towers in the 80's and 90's, with many of them controlling traffic as they had in Pennsy days. Although the Main Line had many tracks, most of them were only signaled in one direction (251 territory in NORAC), so, capacity was limited. This was especially a problem between Royalton and Parkesburg, where Cork in Lancaster was the only controlled crossover location. During track work hand thrown crossovers with manned temporary block stations would have to be used to run traffic, slowing trains in this high speed territory.