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I don't think you will find a definitive answer to this question. Dale Manquen has done a study how many devices it would take to load down the driver circuits and there was not a hard and fast rule to the number of devices. He created a device that would extend the number of devices. I am currently using his device but I use it to connect legacy, a computer, TMCC and a port to driver two TPC's, nine ASC's and four BPC.
We are trying to daisy chain 6, possibly 12 TPC 300's together on a large modular group layout. We have just begun to experment with this. I should have an update in the next day or so. Thanks for the reply. Maybe Dale can add his thoughts.
Check out this post. Might help a bit. JonZ talks about the drive capabilities of the SER2
My guess would be cost. Probably a lot cheaper to use a generic RS232 chip out of China somewhere than one that provides even the meager output supplied by the TMCC unit. As far as the limitations, I believe that Dale Manquen was mentioned as having a signal amplifier device ready made, or you could make your own with some very basic parts.