Martin Jim, & Ed,
Yes, but you have to first take your loco to a full DCS setup and have it reset.
Not necessarily.
First of all, the engine is stated as having been purchased as "new". (Although, "new" on E-bay is open to interpretation.)
Second, even if it's been run, it would have to be have been added to DCS at some point and not been Factory Reset, or it would still be able to work fine with the DCS Remote Commander.
Third, if it needs a Factory Reset, there are hobby shops and clubs where that could easily be done.
Fourth, the older infrared remote noted above is increasingly difficult to find, since it's been out of production for several years. Further, that remote only allows the bell, whistle/horn, direction, and speed control. The DCS Remote Commander allows startup and shut down sounds, remote uncoupling, and PFA operation, as well. This is lots more play value!
Fifth, I volunteered to walk him through its setup. That includes assisting him in resetting the engine to factory specs if he can get it to me.