Yes.
The only thing to be aware of is that you will need to use the CAB-2 to dial up the voltage on your command loop as well. There isn't a way to program the handles so that one will always be at 18 volts and the other will be variable. They either are all controlled by the remote, or none are.
(this assumes your power requirements are within the single channel (handle) capability of the ZW-L, 180W. If you are using a TPC that can deliver more power to the track and paralleling 180 bricks on the input, then this is not the answer for you.)
The need to dial up the voltage for command loops is not a big deal in my mind, but some people used to complain about the ZW-C because it had different behavior when in command mode for the inner and outer handles. (inners would start at the max voltage immediately when in command, the outers would be dialed up to get what you wanted).
Personally, I like they way the old ZW-C outer handles (and now the ZW-L for all handles) work, but some had the opposite opinion, preferring the old ZW-C inner handle behavior of starting at max.
The thing to keep in mind is that the command/conventional switch on the transformer defines the transformer's mode, it has nothing to do with the motive power. Any TMCC/Legacy engine will behave in command mode assuming it can see the base, no matter what the transformer switch is set to.
-Dave