As above, number of rails, size of flanges, type of couplers all have little to do with space required. The way large locomotives go around tight corners is by having undersize cylinders, missing tailbeams, tenders ten feet back, and missing flanges.
A very nice 2-rail layout can operate on 0-27 curves if you either stick with small locomotives and short cars with wide swinging trucks and couplers or run NW2 Diesels. Or allow gross inaccuracies in cylinders, tailbeams, etc.