Basically, American Models, S Helper/MTH and assembled S Scale America cars I leave alone. For Pacific Rail Shops cars (predecessor to assembled S Scale America cars) which no weight was offered in the kits, I would add one ounce of weight above each bolster. This is the same whether my cars are equipped as HiRail or Scale.
Never had any significant trouble with tracking or derailing.
*edit* Whether or not my cars meet the NMRA standard, I don't know, I never bothered to weigh them. However, the weight is pretty consistent among all my rolling stock.
I've found that in the Scale world, wheel gauge and coupler height and movement more important than weight.
Rusty