I found this about the Buick portholes.
A traditional Buick styling cue dating to 1949 is a series of three or four vents on the front fender behind the front wheels. The source of this design feature was a custom car of Buick stylist Ned Nickles, which in addition had a flashing light within each hole each synchronized with a specific spark plug simulating the flames from the exhaust stack of a fighter airplane. Combined with the bombsight mascot (introduced in 1946), VentiPorts put the driver at the controls of an imaginary fighter airplane. The flashing light feature was not used by Buick in production, but VentiPorts remained as nonfunctional ornamentation. Many people jokingly referred to the "ventiports" as "mouseholes".
They were called VentiPorts because the 1949 sales brochure noted that VentiPorts helped ventilate the engine compartment. The suggestion was made that they allowed air flow out of the engine bay. Air entered from the grill into the engine bay and was pressurized by the radiator fan, and exited through the VentiPorts. And possibly that was true in early 1949, but sometime during the model year they became plugged. VentiPorts have appeared sporadically on several models since and are currently featured on three of the four current Buick models.
When introduced, the number of VentiPorts (three or four) denoted the size of straight-eight engine installed. Since displacement differences in straight-eight engines resulted in more dramatic differences in engine length than on V8s, the Buick Roadmaster (which was the only model at this time with the larger engine) needed a longer chassis in front of the cowl to accommodate the larger engine. Thus an extra VentiPort also corresponded directly to the necessary extra length in front. After the more compact V8 replaced the straight-eight engine in 1953 this difference in chassis length was no longer needed. Nevertheless, the convention remained. Consequently, when the Buick Century, which shared the Buick Special's smaller body, was reintroduced in 1954, it also received four VentiPorts to denote its engine's greater displacement. However, in 1955, the Buick Super, which shared Roadmaster's larger body, was promoted from three to four VentiPorts despite having the smaller displacement engine. In turn, the Buick Invicta which took the place of the Buick Century in 1959, and consequently had the smaller body with the larger displacement engine, was demoted from four to three VentiPorts on introduction. Thus the number of VentiPorts came to denote body size rather than engine size. VentiPorts appeared on all Buicks from 1949 through 1957, and on most Buicks (notable exceptions include the Buick Wildcat, the Buick Riviera and the Buick Centurion) from 1960 through 1981.
In 2003 VentiPorts were re-introduced on the Buick Park Avenue. After the Park Avenue was discontinued, Buick salvaged the VentiPorts to appear on the new-for-2006 Lucerne. Consistent with the tradition that held from 1949 through 1954, the Lucerne's VentiPorts refer directly to engine size: V6 models have three on each side, while V8s have four on each side.
Modern and edgy compared to the oval ones that adorned Buicks for years, the new VentiPorts have become a Buick-wide talisman again and are currently featured in one form or another on the Lucerne, the popular Enclave SUV, in 2010, along the inner hood ridges of the redesigned LaCrosse, and in 2012 in the new Buick Regal, only two appear in the hood, maybe referring to the 4 cylinder engine in that car.