Hi Gregg / On my layout at the same time than I am using the Universal Remote, I am also running TMCC, MTH-DCS, traditional locos, and LionChief Plus Remote. There is no interference from these remote systems.
However, you can not have both the original LionChief Plus remote on the same time as the Universal remote, if the Universal Remote is sharing the same loco selector on the Universal Remote. You can use other LionChief Plus Remotes, (Blue in color)
No command base needed. Each loco is on 2.4 GHz and the chip in the receiver and transmitter lock them together.
I also fly radio controlled airplanes, in the old days we had to fly on separate channels. Now we are all on 2.4 GHz. The plane and transmitter will lock onto a channel within 2.4 GHz and sometimes even change during the flight, always staying lock together.
Their is no range issues with the Universal Remote or the LionChief Plus remotes. I can walk up the stairs from my Man Cave and go about 50 feet into the back yard and still be in range,
Yes: It is simple and a lot of fun. Check out this video from my channel.
https://www.youtube.com/watch?v=72_RH1wwp2w
Hope this helps. Gary