Jeff
To run Protosound 2 equipped locomotives and access all their capabilities you will need to buy the MTH
50-1001 DCS Remote Control Set. This includes the DCS wireless remote and Track Interface Unit (TIU). The TIU as 4 channels, each of which is capable of handling 10 amps. Two of the DCS channels (the variable channels) also have the ability to control output voltage so you can use them to run conventionally from your DCS wireless remote.
The MTH TIU has gone through several hardware and software upgrades. The latest hardware version is Revision L. Buying a new "Rev L" TIU is highly recommended. It has improved internal components and has more reliable communication with locomotives thanks to some nifty technology.
MTH also makes cables to connect your TIU to a TMCC or Legacy command base. With the TIU linked to TMCC or Legacy through the cable you can use the DCS remote to operate TMCC or Legacy equipped locomotives in TMCC mode.
Legacy has more features than TMCC. If you want to run your Legacy locomotive and be able to activate all the features you will need to buy the Legacy command control system. Legacy can also control all the features of TMCC locomotives.
Both DCS and TMCC/Legacy locomotives
can and often
do operate at the same time on a layout and coexist nicely. However, each system has some technical quirks that can cause impediments to reliable communication. Those quirks and the techniques to address them are known and quality advice is available here on the OGR TMCC/Legacy and DCS forums.
My suggestion to you is to go ahead and buy DCS and hook it up to your layout. Run trains and use the DCS signal strength check feature. Most layouts work well with DCS right off the bat. If you have some problem areas read the Barry Broskwitz
Ten Commandments of DCS and follow them. By following the Ten Commandments of DCS and by addressing a few things that help TMCC/Legacy (good grounding, no wire for plaster hardshell scenery and consideration for parallel yard tracks) you can have locomotives from all 3 rail manufacturers running together on your layout and be able to enjoy them to the fullest.
Note regarding the Ten Commandments: With Rev L TIUs the light bulb trick is not necessary.