The San Diego Museum has a 2-rail section, and I get the maintenance tasks. We run 8 hrs a day, six days a week. MTH so far has the best reputation by far for longevity and ease of replacing parts. We go through axle gears about every two-three years, worms get replaced on about the third axle gear, or almost a decade, and only one unit has required new axles and axle bearings. So far, no motor problems. My experience is maybe a quarter- century with these units.
All-Nation 2-rail transmissions did not last a year, and could not be economically fixed. Atlas Diesels are more difficult to work on, and while Atlas has been very gracious at supplying parts, they are often out of stock. Weaver gave us a 2-rail Diesel a decade ago. It is still running, but like Atlas, it is a bit more difficult to keep it going.
We do wear out steam, but it is rare, and usually it is just the side rods. Easy to re-bush. Early Max Gray steamers had brass crank pins - they get replaced with steel.
The average individual with a passion for model trains will never wear out a good model.