To say that you never saw a road failure on an SD45/SD45-2 is to say that you were probably running relatively new units ! Did you always check the status of all your trailing units at the end of a run?
When I worked in the Mechanical Dept of Union Pacific Railroad 1978-1981 we read the locomotive failure reports every morning and I can tell you that our SD45's had more than their share of failures. UP only had 50 of them, and by that time they were getting to be older units with high mileage. They were mostly assigned to drag service on coal trains so they saw hard use. The UP SD45's also had more than their share of overheat-overspeed turbocharger failures, and we were never able to conclusively figure why, but I believe it was due to less than top quality with UP's in-house rebuilt engine components (not the turbos themselves; they were sent out to rebuild specialists). The turbos were pretty similar on the 16 cylinder and 20 cylinder engines but they had to work harder for more cylinders. We had extensive data and statistics on turbocharger failures over many years. As the UP SD45's became older and more problematic, one unit received a Sulzer engine as a trial replacement for the 20 cylinder engine.
Hot Water will probably straighten me out on details, but as I recall the 20 cylinder engines had the same air filters as a 16 cylinder engine, yet they were feeding four more cylinders and changed out on the same 90-day maintenance schedule. I can't remember for sure but it might have been the same thing with the engine oil filters and fuel filters. I think the 20 cylinder engines were taking more of a beating as they aged.
A lot of SD45's survived because some railroads, notably SP and ATSF, bought them in great quantity so naturally they wanted to keep them going. Lots of them got passed along to the secondhand market. Some of them even had turbochargers removed in their final years as "heavy-duty switchers". But overall, the SD45's were more likely to be retired earlier than an SD40.
Railroads bought the SD45's for more horsepower in one package, yet they had the same traction motors as an SD40/SD40-2. At lower speeds the power to the traction motors derated so that the SD45's were no better than a SD40 at drag speed, otherwise they would burn up the traction motors.
The SD40/SD40-2 ultimately proved to be a more popular and more reliable locomotive than the SD45's.