Major differences in track types on a layout always bugged me personally. I'm a user of tubular track and have used O Gauge (Black Tie) and O-27 (brown tie) in the same layout. They are close enough that you can't really tell the difference unless you know where to look. See a photo of my old layout below...it is a mix of O and O-27.
My current layout is all 0-27 on grey indoor/outdoor carpet with Ross switches. Ross and tubular are about as far apart in similarity (appearance wise) as you can get but it doesn't bug me as Ross switches are the best of the best and I have no problem overlooking the extra ties for functionality. Tubular switches/Lionel had always given me headaches but not enough to rip them all out although I did with one on the old layout.
What DOES bug me is using tubular and Realtrax or Realtrax and Fastrack, etc on the same layout...just looks strange.
Below is my old layout, O and O-27 tubular with Ross and Lionel switches. Didn't bother me. Outside of the Ross switch, you could hardly tell the difference in track/switch types.
I've been a member of the National Capital Trackers for almost 10 years. The standard is Lionel Tubular Track (O Gauge, Black Tie) however over the years, that has morphed into whatever track you want. I've always been a proponent of ONE track type not only for looks but functionality. The Trackers are currently making changes to their standards and once again, I've mentioned requiring and enforcing the Lionel tubular track. You'll see Fastrack, Realtrax, Tubular, Gargraves, Atlas, etc on a single layout and, IMHO, it looks terrible and can cause operational problems.