Not exactly, but the Misty Moutain RR has several attributes. The gentleman, from memory, I think his name is Charles Griffin, a native Georgian who I believe has roots that went back to the antebellum days, made sure to have several key buildings on his layout from historic and antebellum Georgia, as well as the theater where Gone with the Wind premiered. I think part of his layout also features the rail route where Yankee "plainclothes" soldiers hijacked a Southern train to attempt to sabotage the rails - I think there are some civil war historical event vignettes too. I believe Mr. Griffin welcomes people daily to see this amazing layout too.
By the way, if I were to model this era, I would do either Atlanta or New Orleans. Atlanta because it was the nerve center of the railroad supply lifeblood of the South and Georgia was under siege for a long, long spell, with Gen. Joe Johnston (probably the greatest tactician of the era) protecting the rails/Atlanta for this very reason - so there is much railroad related historical significance. New Orleans because I heard the tales from grandma how her mother and other women were throwing pots of boiling water and oil off the balconies in the French Quarter down on Yankee soldiers, as they marched in. Also, it was the terminal point for the bourbon trade coming down the river from Louisville. Finally, it was also a very historic rail hub during the war, so vignettes would be incredibly interesting and lively.
Peter