Mike; a few comments that may be useful LOL! My layout is close to 30 years old, built long before DCS, when TMCC was just in its infancy. Its all old school block wired, with center rail block insulators. It has no right to work as well as it does, but I have run TMCC/Legacy/DCS now for about 15 years and all works quite well. Overall size is 14' x 22' with about 400 feet total track, so it is similar size to your planned layout. Switch and accessory power are supplied via separate dedicated supplies.
I run one TIU only with all channels in use. Variables are set to fixed, and one Z-4000 supplies all track power. Each Z-4000 output is split to two of the TIU inputs. Power distribution is by Curtis barrier terminal strips. I can run several trains at once, but rarely run more than two. Passenger cars are all converted to strip led lighting so they draw only a small fraction of what incandescent lit cars would. I run only command, no conventional these days.
Track wiring does not follow a well defined star pattern, and the blocks are not powered by wire pairs at all. Blocks are switched by several ganged Atlas 4 pole A-B switches (that have been around for decades). I have a TT with 12 whisker tracks, selected by one rotary 12 pole switch. Another 12 pole rotary switch powers any one of 9 different main yard tracks. A 6 pole rotary powers tracks in a secondary yard. A DCS remote commander with a perpetual watchdog chip injects continuous watchdog signals into the yard and TT tracks so that any DCS engine on the selected track stays dark until startup.
I use TVS's on all transformer outputs as well as at major terminal strip points. I can run TMCC. Legacy and DCS all at the same time without interference. And it has all worked amazingly well! Better than it has any right to!
Rod