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Good question - I would expect so as mainline clearances have been improved to handle double stack trains on the former Middle and Pittsburgh divisions. The old double track tunnels at Gallitzin and Spruce are now single track with lower floors. Passenger platforms and shelters (like the one on the super-elevated curve at Tyrone, PA) had clearance issues - but they're mostly gone. Large locomotives like the big S2 steam turbine made a limited number of test runs over the Middle and Pittsburgh divisions but were restricted as to which of the 4 tracks they could run on. Perhaps an NS employee can shed some light for us on any current clearance issues on NS main lines in central PA.
Ed Rappe