I know that the original GE "pre U25" demonstrators (R/N 751 and 752) had "grapevine" throttles, with the handle exiting a box mounted forward near the cab ceiling. Later production U25B's and C's had a 16 notch wonder. The thought behind the 16 notch throttle was that the odd numbered notches just increased main generator excitation as a way of minimizing the jump in tractive effort from notch to notch, to aid in train handling. (Keep in mind that at this time the "standard" road freight locomotive was a EMD F7 with 1750 HP. A U25B had 2500 THP.)
Since there were "three or four" switchers every 20 miles or so, there was absolutely no thought that a U25 would ever have to switch! Additionally, it was impossible to "sweep" the throttle as each notch had a detent. This design choice made a locomotive with a four stroke diesel engine and an exhaust driven turbo load even slower. GE was roundly criticized for this design choice, and justifiably so.
After some time, and an accident where an engineer told the ICC investigator that he became "confused" re the throttle operation due to differences between a GE and a EMD, the AAR came up with a standard set of design guidelines, including 8 notches, size and placement of the reverse lever, throttle sweep in degrees arc, etc. GE redesigned its master controller to comply with that requirement.