Our club's layout is just about operational to run some trains on the two large loops. I was away for a few weeks when we were in 'the throws of moving' and the basic wiring was complete when I was able to come back to work. What they did was create two blocks on one loop using the bus wiring system and had our Z4000 wired to each block with the second loop wired to a Lionel CW-80.
There are several crossovers (with gargraves switches) between the loops but they are supposedly isolated from each other.
My question is are there any concerns running PS2 and Legacy engines from loop to loop with the two different transformers in play?