I purchased 2 CW-80's for my son's 4x8 layout and have had problems with both. First failed CW-80 voltage would not reduce to zero when throttle was set to 0. At throttle position 0, the transformer was still putting out 10.5 volts. This has been RMA repaired by Lionel (in route to me now).
The second CW-80 did the same thing but then stopped powering on entirely. This is also going back to Lionel for RMA. Most likely both were cause by minor derailments on my son's small 4x8 layout and the internal fuse was blown. (my guess as Lionel did not state what the problem was). Note that I used a GW-180 as a fill in on this layout with no issues.
I have since installed 2 new MTH Z-1000 transformers and all appears well (just installed so can't verify 100%). I believe the Z-1000's will do a better job as the power bricks have a circuit breaker. So if there is a derailment, I can reset the breaker instead of an internal fuse being blown. Also, the Z-1000 were less expensive, has a bit more power (100W vs 80W), and from what I have read, the Z-1000 power (sine wave) is more compatible with MTH locos (though I do not own any at present, most my locos are all Lionel with 2 Williams).
I was hopeful that these revised CW-80's would have resolved the known issues with past CW-80's. I went with these as a more budget friendly solution to power my son's 4x8 layout. IMO, these are a terrible value given how easily they failed (very minor derailment of James on a turnout which killed the 2nd CW-80 instantly.) I will use one of the RMA CW-80 in a ceiling loop I am building in my office and the other one will probably be used for accessory power either on my primary layout or future expanded layout for my son.