Agree with the others about the basic design, with the dimensions you have you should use as large a curves as possible, as GRJ said it makes anything look better. With the open end on one side, you theoretically could do a U shaped layout, the problem is that would limit the max curve size on the two legs for the return leg. An oval/around the room layout has the problem of needing a pass through/duck under at the open end of the layout, to allow access to the middle of the layout. The good news is with a 13 foot width, you can build it where you have full access to the outside of the layout as well as the inside, so you can build the layout wider (with access from outside and inside possible, you could do a 60" wide layout base, 30" reach from inside/outside.
It is good you already have started thinking about what you want on the layout, because of course that informs the design. There are also things like do you want grades on the layout, or are do you want it pretty much level? What kind of scenes do you want to model, do you prefer trains going through rural areas or a more urban look? These all will inform what you do with the design of it. I tried using design software, RR Modeller and scarm and the like, and I ended up with Rail Modeller pro on the Mac, but you might find one of the others works. The other thing there is no disgrace in getting help laying it out, there are pro services who advertise in OGRR , and there are people on forums like this that enjoy designing plans, giving suggestions.
There are a variety of ways to build the layout itself, some people use modular train tables from Miannes and others, most tend to build it themselves. I built my table using a ladder approach (basically a rectangular box with 1x4's every 16" across) and am doing an experiment using 4" foam over plywood for the base. There plenty of methods.
Then there is track and control system. Given your rolling stock being modern, I would say you would be smart wiring for Cab 3 and DCS, and using the capability of DCS to run conventional engines via the variable output. I use Ross track and switches and am really happy with it. Note that others use Gargraves track that is very similar to Ross (and is fully compatible with Ross), especially the Gargraves flex track.
And yes it can be overwhelming. If the basement space is not finished off, you may want to do that if possible, to make it pleasant to be there . Make sure you have enough power accessible in the space, lighting, and you do want to make sure it is comfortable for you and the trains, in terms of heating/cooling and humidity (and if your basement already has all that, congrats!). I didn't do carpeting because my basement has the potential to get water, but having that or rubber tiles can make it more pleasant.
One of the biggest things is having a plan for all this, having that kind of allows you to see what you need to do and check off what you have done, to show progress.
There are decent books on layout building that can be a help, that go over the basics that you might even be able to find in the library or from sellers of toy train books.
One thing to know, mistakes happen, few people's first layouts are perfect and plans can always be changed. Once you start building the track you get an idea of what it will look like, and you might change your mind. Also know that with design programs, there is always fiddling in the build phase (ask me how I know!).
This is obviously just a quick bunch of thoughts. One thing I encourage, ask questions on here, people here genuinely want to share and help others. There will be disagreements, someone will say "X is the way to go", others will say "Y is it", in the end though it is what you want. If you just want to run trains, that is fine. If you want to try and do realistic operations (which influences the design), that is fine and it may change over time.