TMCC with a CW-80???

Personally, I'd probably use the CW-80 for accessories and use a different transformer.  If you want to use the CW-80, you connect it to the track just like you would for conventional, then wire the TMCC command base to the outside rail.

You won't damage your TMCC locomotive, though the CW-80 has had it's share of issues with electronic boards in locomotives.  The issues usually result in operational issues, not actually board failures.

I would recommend a TVS across the track outputs of the transformer, just in case.

One wire from the command base "U" terminal post to the layout common outside rails.  The connection can be made anywhere, at the track, a terminal block, transformer, eg.

A TVS (Transient Voltage Suppression diode) is a device that you wire directly across the track voltage to suppress spikes that exceed it's rated capacity.  It's used to protect your train electronics from harmful voltage spikes.

Here's the one I use: 1.5KE36CA at Digikey

Thanks John!

While I was hunting for a local source of good 18v transformers, I ran my layout using 2 CW-80 transformers. These were set-up with one on each loop, and the outer rail of each loop was connected together for connection to my Legacy base. TMCC should work fine too, especially if you use a TVS as advised above.   I run on 50Hz power as well, so if there were any likely problems with the CW-80, I'm pretty sure that I should have encountered them.