The RailSounds Commander is the complete sound package, all you need is the serial data from a TMCC receiver to trigger the sounds. You can use the RailSounds Commander with the ERR TMCC products that provide a serial output (virtually all the TMCC "Commander" products).
You could use it with a standard Lionel TMCC package if you tap off the serial output, but that's probably not used that often. Most Lionel packages provide for the plug-in of the standard RailSounds audio and power supply boards.