No regrets, just wish I had a larger, dedicated room to work with. As such I have no experience with an around-the-room layout (as much as I would like) but instead just large ovals.
Working with 072 or larger is going to require some planning. For me, it is easier to envision a track plan and then throw together O36 to see how it looks and works than it is for O72. For O72 I often realize that my mind's eye overestimates how much I can do with O72 in a smallish space, which doesn't become evident until I jump into track planning software. If you are working with a relatively small space, you will not have much room for creative track plans and will probably be stuck with a large oval.
Additionally, the space requirements do not leave you with a lot of room for switches to fill the inside with yards or other additional inner tracks, unless you are willing to devote a lot of space to the loop or you use tighter radii on the inside. The different O72 loop floor layouts I have done (between 50 and 80 sqft) have all had O36 yard tracks. I have some O48 track which in many of my plans served as either a full loop encompassing the inner yard or a half-loop serving as a long yard lead, with an O60 and O72 loops forming a double track mainline. Again, because of the space requirements and the limited room I have to devote to a layout, these have all been plain oval loops.
As others have said, as long as you're smart about it, you will absolutely never regret it.