Good question, good thread!
I think I've finally 'crossed the bridge' on this one. To create a leaf-spring archbar truck for an Ambroid caboose model to run on my O3R layout (Gargraves/Ross, O72 Min.) I found some old metal Athearn kit wheels with slightly deeper flanges that worked just fine in a pair of Athearn plastic archbar truck frames, sustituting Precision Scale leaf springs for the coil springs. The metal wheels, besides tracking just fine throughout the layout, also offered an easier way to power the marker/interior lights in the 'boose from the track (found a center roller assembly in the parts bin that was easy to attach to the Athearn truck for center rail pickup).
So, yes, I would say there's an excellent chance that O2R wheelsets will work on O3R track, especially that having an appropriate rail cross-section...e.g., Gargraves, Ross, Scaletrax, Atlas, early Realtrax, and maybe others.
Worth a try, anyway, because there are some increased choices available to the O3R hobbyist when doing this!!
KD