My regional/short line background is showing in my "wheel wear" comment.
When I was superintendent for the Ohio Central RR in Youngstown, Ohio, we ran a 35-mile line south to Darlington, PA that had more and sharper left-hand curves going south than right-hand curves. We typically assigned the same four units to these trains. It took four units because the loads went south and right out of the yard we had a 2-mile long, 2% grade. Further south was another 5-mile long, 1.6% grade.
After we had been running this line for several months we began to notice uneven flange wear on the units assigned to these trains. We figured that it was due to the preponderance of left hand curves on this line. We turned the whole set of power on a nearby wye, and after several more months the flange wear evened out.
Big Jim, you are right in that on the big Class 1 railroads where you work there would be no need to turn engines to equalize wheel wear.