Below is an admittedly complex layout that I'm thinking of building for a mountain themed layout. I'm limited to a 10x10 space so the layout itself is 9x9 with three tiers to try to make the most of the space I have. The grey section is the lower level at a table height of 3 1/2ft. This section contains the most tunneling and is level for the entirety of the section. The green section is the rapid incline portion that transitions up 7 1/2in at a 4.5% grade to the red section. The red section will be where the town is atop a large hill (of which the shape is subject to change) and remains flat @ 7 1/2in in height. All of these sections are no more than O-48 and no less than O-36. The blue section is O-72 for my largest train since it is limited to that gauge. The blue section transitions up another 5.5in until it flattens out on the backside and also tunnels through the backside of the layout.
Both engines are powerful enough to climb these grades with the 5-car loads they will be hauling but I've never done a layout where such a steep incline/decline are nearly constant(for the O-72) so I'm not sure how adversely it will effect the engine. The grade can be lowered if 4.2% grade is likely to cause too many failures. The both engines have speed control. The Engines are a JLC Big Boy and LionMaster Challenger.
Any thoughts/tips/critiques would be appreciated especially on clearances.