Visually, I wouldn't expect a major change.
Operationally, the railroad landscape may look totally different. Over the next few years, Class 1 railroads will begin to sell, downgrade or railbank more routes. They want to become more efficient and the best way to do that is to concentrate the traffic onto select lines and eliminating parallel routes. Even if this means traffic may take a few days longer to get to its destination. Lines that just a few years ago would see 10-15 trains a day, with 60 mph track, will be regulated to 25 mph branch lines with just 2 trains a day.
This also means short lines and regionals will gain even more track. We may see new regionals pop up in the coal fields, G&W may gain access to St. Louis, and Watco may grow to be the biggest carrier in North Carolina. There's going to be a lot of opportunity out there for these companies. Also, because of this, I'd expect a lot more rebuilds of second and third generation locomotives.
That's just my two cents on it.