Recall seeing a photo of a Northern Pacific 4-8-4 with a broken spoke driver.......the entire tread was hanging off the side rod, exposing naked spokes suspended in the air.
The Burlington used boxpok center drivers on their 64" drivered 2-10-4's, when they rebuilt them in the '30's for higher speed freight service to Denver (55 mph max). A bit more interesting was the use of a center boxpok driver on the Burlington's 60" drivered, WW I era 2-10-2's, in an attempt to coax more speed out of those plodding fat-soes! And, these same boxpok drivers had counterweights inside the frame, in addition to the counterweights on the wheel, again to counteract the dynamic augment of all the reciprocating machinery at speed. Burlington's primevil O2 and O3 WW I era 5300-series 2-8-2's also had boxpok center drivers. Presume all of this was to forestall driver failures at higher speeds.
As with most things steam locomotive, the N&W perhaps greatly improved spoke drivers.......better metallurgy?