I tend to overdo things, and what I'm about to say is an example.
I have at best a moderate-size layout with 2 main lines with reverse loops on each end, one main line is about 40 feet long, the other main line about 25 feet long. I have one Z4000 that powers both independently powered, interconnected main lines: each throttle controls a main line.
Now, I will share the overdone part. I have another Z4000 that powers 8 independently powered sidings and 1 passing siding. I use Atlas Heavy Duty connectors/switches to turn power on and off for the sidings.
Next, is the outrageously overdone part. I have a 3rd Z4000 to provide power to one more long siding, two short sidings and a few accessories.
It's an understatement that I've been extravagant powering my moderate-sized layout with three Z4000s.
The reason I have three Z4000s is that when there was speculation that MTH might go out of business 2 or 3 years ago, I went a little crazy buying MTH products to stock up for the duration, including buying 2 more Z4000s. I already had one I was very happy with that I bought early on in the mid to late 1990s.
More extravagance: I have two ZWs; one powers my sixteen 022 switch tracks, the other powers numerous Postwar accessories on my layout, again using Atlas Heavy Duty connectors/switches.
So, Terry, what I would do if I were you is buy another Z4000, and then you would have a separate Z4000 throttle to power each of your 4 main lines. And, by doing that you would have a spare Z4000 in case one of them breaks down and can't be repaired. IMO, the Z4000 is an excellent transformer.
My approach is definitely not the most economical way to go. Arnold